In this work, a series of N-substituted isatin derivatives was synthesized by different reactions.
The synthesized isatin derivatives were characterized by NMR, MS and elemental analysis.
Then the anti-tumor activities of these compounds were evaluated through the cytotoxicity against A549 and P388 cell
line test. The results show that several compounds show much higher anti-tumor activity than that of isatin, and there is an
even-odd effect in the structure activity relationship.
Keywords: Isatin, derivative, synthesis, anti-tumor, neuro-protection, even-odd effect
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