Synthesis, Anti-tumor Activity and Odd–even Effect of Simple Isatin Derivatives

Author(s): Gang Chen, Xiaojiang Hao, Ye Wang, Shuzhen Mu

Journal Name: Letters in Drug Design & Discovery

Volume 12 , Issue 10 , 2015

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Graphical Abstract:


In this work, a series of N-substituted isatin derivatives was synthesized by different reactions. The synthesized isatin derivatives were characterized by NMR, MS and elemental analysis. Then the anti-tumor activities of these compounds were evaluated through the cytotoxicity against A549 and P388 cell line test. The results show that several compounds show much higher anti-tumor activity than that of isatin, and there is an even-odd effect in the structure activity relationship.

Keywords: Isatin, derivative, synthesis, anti-tumor, neuro-protection, even-odd effect

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Article Details

Year: 2015
Page: [813 - 818]
Pages: 6
DOI: 10.2174/157018081210151012120940
Price: $65

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