Cardiovascular diseases (CVDs), primarily myocardial infarction (MI), atherosclerosis, hypertension and
congestive heart failure symbolize the foremost cause of death in almost all parts of the world. Besides the traditional
therapeutic approaches for the management of CVDs, newer innovative strategies are also emerging on the horizon. Recently, gene
silencing via small interfering RNA (siRNA) is one of the hot topics amongst various strategies involved in the management of CVDs.
The siRNA mechanism involves natural catalytic processes to silence pathological genes that are overexpressed in a particular disease.
Also the versatility of gene expression by siRNA deciphers a prospective tactic to down-regulate diseases associated gene, protein or receptor
existing on a specific disease target. This article reviews the application of siRNA against CVDs with special emphasis on gene
targets in combination with delivery systems such as cationic hydrogels, polyplexes, peptides, liposomes and dendrimers.