Abstract
Background: Diabetes mellitus (DM) is a widespread chronic metabolic disease which has high mortality due to its complications. In addition to traditional medication, stem cell transplantation therapeutics has become a brand-new and prospective remedy for DM. With strong self-renewal and multi-potential ability, mesenchymal stem cells (MSCs) are considered as ideal cell sources of cell therapy for DM and many other diseases. However, not only do endogenous MSCs fail to replace the impaired islet cells, but also transplanted MSCs fail to cure many patients complicated with DM. Besides, quite a few DM patients suffer from high risk of fracture and low efficiency of bone regeneration, which are often associated with the osteoblastic differentiation of MSCs. Recently, a number of researches have investigated that the changes in micro-environment by DM can affect biological characteristics of MSCs through many factors.
Summary: In this review, we summarize the developments in the influence of DM on proliferation and osteoblastic differentiation of MSCs, and moreover, osteoporosis, obesity and metabolism syndrome, as they are closely related to DM.Keywords: Diabetes mellitus, mesenchymal stem cells, proliferation, osteoblastic differentiation, osteoporosis, obesity, metabolism syndrome
Current Stem Cell Research & Therapy
Title:The Influence of Diabetes Mellitus on Proliferation and Osteoblastic Differentiation of MSCs
Volume: 12 Issue: 5
Author(s): Jun Tan, Lihua Zhou, Yang Zhou, Peng Xue, Guangsheng Wu, Guangying Dong, Hang Guo and Qintao Wang*
Affiliation:
- Department of Periodontology, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi`an, Shaanxi 710032, P. R. China,China
Keywords: Diabetes mellitus, mesenchymal stem cells, proliferation, osteoblastic differentiation, osteoporosis, obesity, metabolism syndrome
Abstract: Background: Diabetes mellitus (DM) is a widespread chronic metabolic disease which has high mortality due to its complications. In addition to traditional medication, stem cell transplantation therapeutics has become a brand-new and prospective remedy for DM. With strong self-renewal and multi-potential ability, mesenchymal stem cells (MSCs) are considered as ideal cell sources of cell therapy for DM and many other diseases. However, not only do endogenous MSCs fail to replace the impaired islet cells, but also transplanted MSCs fail to cure many patients complicated with DM. Besides, quite a few DM patients suffer from high risk of fracture and low efficiency of bone regeneration, which are often associated with the osteoblastic differentiation of MSCs. Recently, a number of researches have investigated that the changes in micro-environment by DM can affect biological characteristics of MSCs through many factors.
Summary: In this review, we summarize the developments in the influence of DM on proliferation and osteoblastic differentiation of MSCs, and moreover, osteoporosis, obesity and metabolism syndrome, as they are closely related to DM.Export Options
About this article
Cite this article as:
Tan Jun, Zhou Lihua, Zhou Yang, Xue Peng, Wu Guangsheng, Dong Guangying, Guo Hang and Wang Qintao*, The Influence of Diabetes Mellitus on Proliferation and Osteoblastic Differentiation of MSCs, Current Stem Cell Research & Therapy 2017; 12 (5) . https://dx.doi.org/10.2174/1574888X10666151001114527
DOI https://dx.doi.org/10.2174/1574888X10666151001114527 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
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