Title:Current State of ERG as Biomarker in Prostatic Adenocarcinoma
VOLUME: 15 ISSUE: 8
Author(s):Balazs Acs, Tibor Szarvas, Nora Szekely, Peter Nyirady and A. Marcell Szasz
Affiliation:2nd Department of Pathology, Semmelweis University Budapest, Address: 93 Ulloi ut, Budapest 1091, Hungary.
Keywords:Diagnosis, ERG, prognosis, prediction, prostate carcinoma, TMPRSS2.
Abstract:In this review we briefly discuss the possible biomarkers of prostate cancer among them
we focus and analyze the relevance of TMPRSS2-ERG fusion gene in line with ERG expression in
the diagnosis of prostate cancer. Starting at diagnosis and genetic alterations in prostate carcinomas,
we examine the incidence and detection of the most common genetic aberration in this tumor and its
protein product as well. We also examined the correlation of clinicopathological factors and
prognosis with ERG and the TMPRSS2-ERG fusion oncogene and ERG expression as predictive
markers.
