Fullerenes being allotropes of carbon, have been considered as new class of molecules. Unlike
diamond and graphite, this is made up of hollow carbon cage structure. The idea of spheroidal
cage structures of C60 arose from construction of geodesic domes made by renowned architect Buckminster
Fuller. Although fullerenes have low solubility in physiological media they finds promising
biological applications. The photo, electrochemical and physical properties of C60 and other fullerene
derivatives finds applications in medical fields. The ability of fullerenes to fit inside the hydrophobic
cavity of HIV proteases makes them potential inhibitor for substrates to catalytic active site of enzyme. It possesses radical
scavenging and antioxidant property. At the same time, when it exposed to light it can form singlet oxygen in high
quantum yields which with direct electron transfer from excited state of fullerenes and DNA bases finally results in cleavage
of DNA. The fullerenes are also used as a carrier for gene and drug delivery system. The associated low toxicity of
fullerenes is sufficient to attract the researchers for investigation of these interesting molecules.
Keywords: Applications, buckyball, C60, drug delivery, fullerene, toxicity.
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