Hyperuricemia leads to insulin resistance, whereas insulin resistance decreases renal excretion
of uric acid, both mechanisms link elevated serum uric acid with metabolic syndrome.
The aim of this study is to evaluate the probability for the development of metabolic syndrome in
low-income young adults with hyperuricaemia.
Methods: We evaluated 103 patients less than 40 years of age, from a low-income population, and
without history of cardiovascular disease, in all of them the presence of metabolic syndrome was assessed
in accordance with the International Diabetes Federation criteria.
In all patients, fasting serum uric acid levels were measured; hyperuricaemia was defined as serum
uric acid values > 6.5 mg/dl in men and > 5.1 mg/dl in women. Statistical analysis was performed
with odds ratio.
Results: 83 of our patients (80.5%) suffered metabolic syndrome, the odds ratio for the presence of
metabolic syndrome in patients with hyperuricaemia was 5.1 (p=0.002, I.C 1.8- 14.5). When patients
were evaluated by gender a significantly association between hyperuricaemia and metabolic syndrome
was found in women (odds ratio 3.6, p=0.048, C.I. 1.0-12.9), and men (odds ratio 10.2, p=
0.015, IC 1.5-13.2). When uric acid was correlated with the components of metabolic syndrome, we
only found a positive correlation with waist circumference (r=0.483).
Conclusion: Our results showed a significant association between hyperuricemia and metabolic syndrome
in low-income young adults in Mexico. DR is associated with estimated risk of CVD in type 2