Intracellular calcium homeostasis plays a fundamental role in the electric and mechanical
function of the heart by modulating action potential pattern and duration, by linking cell membrane
depolarization to myocardial contraction and by regulating cardiac automaticity. Abnormalities of intracellular
calcium regulation disrupt the electrophysiological properties of the heart and create an arrhythmogenic
milieu, which promotes atrial and ventricular arrhythmogenesis and impairs cardiac
automaticity and atrioventricular conduction. In this brief review, we summarize the basic genetic, molecular and electrophysiological
mechanisms linking inherited or acquired intracellular Ca2+ dysregulation to arrhythmogenesis.