Total Synthesis of ME1036 Starting from Readily Available Inexpensive Materials

Author(s): Zhi-Jian Han, Yang-Bing Li, Lu-Xi Yang, Ai-lin Song, Hao Chen, Yu-Min Li

Journal Name: Letters in Organic Chemistry

Volume 12 , Issue 10 , 2015

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Abstract:

This work demonstrates the effective total synthesis of a new broad-spectrum parenteral carbapenem starting from the readily available and inexpensive N-Cbz-protected glycine amide in high yield with easy work-up under mild reaction conditions.

Keywords: Carbapenem, C-C coupling, diazo compound, glycine amide, ME1036, total synthesis.

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Article Details

VOLUME: 12
ISSUE: 10
Year: 2015
Page: [745 - 752]
Pages: 8
DOI: 10.2174/1570178612666150924001523
Price: $65

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