Antithrombin, an Important Inhibitor in Blood Clots

Author(s): Ying Zhu, Qing-Wei Cong, Yue Liu, Chun-ling Wan, Tao Yu, Guang He, Lin He, Lei Cai, Kuo-Chen Chou

Journal Name: Current Topics in Medicinal Chemistry

Volume 16 , Issue 6 , 2016

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Graphical Abstract:


Blood coagulation is healthy and lifesaving because it can stop bleeding. It can, however, be a troublemaker as well, causing serious medical problems including heart attack and stroke. Body has complex blood coagulation cascade to modulate the blood clots. In the environment of plasma, the blood coagulation cascade is regulated by antithrombin, which is deemed one of the most important serine protease inhibitors. It inhibits thrombin; it can inhibit factors IXa and Xa as well. Interestingly, its inhibitory ability will be significantly increased with the existence of heparin. In this minireview paper, we are to summarize the structural features of antithrombin, as well as its heparin binding modes and anti-coagulation mechanisms, in hopes that the discussion and analysis presented in this paper can stimulate new strategies to find more effective approaches or compounds to modulate the antithrombin.

Keywords: Antithrombin, Hemostasis, Heparin, Blood clot.

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Article Details

Year: 2016
Page: [666 - 674]
Pages: 9
DOI: 10.2174/1568026616666150923152745
Price: $65

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