Aripiprazole, a dopamine stabilizing atypical antipsychotic is used in treatment of tardive dyskinesia caused by
other neuroleptics. Tardive dyskinesia is rarely caused by Aripiprazole and has only been documented in high risk patients
i.e., female gender, advanced age, affective illness, coexisting neurological disorders. Here the author describes two
atypical cases of tardive dyskinesia associated with Aripiprazole. First case of tardive dyskinesia was observed in a
neuroleptic naïve young adult male with paranoid illness after six months of treatment with Aripiprazole upon addition of
Fluoxetine and the second case was a middle aged female with affective illness where dyskinetic movements appeared
after stopping Aripiprazole. The role of Fluoxetine in causing tardive dyskinesia with Aripiprazole and covert dyskinesia
due to Aripiprazole with appropriate management is discussed.
Keywords: Aripiprazole, covert dyskinesia, tardive dyskinesia.
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