Down syndrome is an intellectual disability requiring periodic monitoring of cognition
given the near universal presence of Alzheimer’s Disease related neuropathology and high rates of
dementia in middle adulthood. We review current approaches to detecting decline in this population,
including informant-based measures, dementia screening tools, and neuroimaging techniques. The
challenges for detecting decline in this group are discussed, including the need to take into account
premorbid cognitive function as well as medical comorbidity.
Keywords: Alzheimer’s disease, assessment, decline, dementia, down syndrome, neuropsychological, sleep.
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