Green Approach to Stereoselective Synthesis of Benzo[d]chromeno[3,4- h]oxathiazonine Derivatives via MCRs in Water: A Combined Experimental and DFT Study

Author(s): Hoorieh Djahaniani, Farzaneh Fatemi, Fatemeh Ektefa, Bita Mohtat, Behrouz Notash

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 18 , Issue 10 , 2015


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Abstract:

(7S, 14S, 16R)- dialkyl 6-oxo-6,7,13,14-tetrahydro-7,14-methanobenzo[d]chromeno[3,4- h][1,6,3]oxathiazo-nine-14,16-dicarboxylates 4 and (S)-methyl 2-(2-methoxy-2-oxoethyl)-2,3- dihydrobenzo[d]thiazole-2-carboxylates 5 were readily synthesized in a ratio 3:1 and moderated yield by multicomponent reactions of 4-hydroxycoumarin and acetylenic esters with benzothiazole without using a catalyst. Also, The GIAO/DFT approach at the B3LYP/6-31G** level of theory was used to calculate the 1H, 15N, 17O and 13C NMR chemical shifts of product 4b. These computations are performed on the basis of X-ray structural data which are collected at 120(2) K temperature. In order to take into account intermolecular hydrogen bonds and the van der Waals effects, two different sizes of clusters (two model of trimeric and pentameric clusters) have been considered. A comparison between the experimental (Exp.) and calculated (Cal.) 1H and 13C NMR chemical shifts may reveal that the solution contains monomer, trimer1, trimer2, and pentamer models.

Keywords: Multicomponent reactions, chromeno[3, 4-h][1, 6, 3]oxathiazonine, dihydrobenzo[d]thiazole, benzothiazole, hydrogen bond, DFT study.

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Article Details

VOLUME: 18
ISSUE: 10
Year: 2015
Published on: 03 November, 2015
Page: [990 - 999]
Pages: 10
DOI: 10.2174/1386207318666150915113230
Price: $65

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