Carbazole Scaffold in Medicinal Chemistry and Natural Products: A Review from 2010-2015

Author(s): Lissa S. Tsutsumi, Daniela Gündisch, Dianqing Sun

Journal Name: Current Topics in Medicinal Chemistry

Volume 16 , Issue 11 , 2016

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Graphical Abstract:


9H-carbazole is an aromatic molecule that is tricyclic in nature, with two benzene rings fused onto a 5-membered pyrrole ring. Obtained from natural sources or by synthetic routes, this scaffold has gained much interest due to its wide range of biological activity upon modifications, including antibacterial, antimalarial, anticancer, and anti-Alzheimer properties. This review reports a survey of the literature on carbazole-containing molecules and their medicinal activities from 2010 through 2015. In particular, we focus on their in vitro and in vivo activities and summarize structure-activity relationships (SAR), mechanisms of action, and/or cytotoxicity/selectivity findings when available to provide future guidance for the development of clinically useful agents from this template.

Keywords: Biological activity, Carbazole, Natural product, SAR, Scaffold, Small molecule

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Article Details

Year: 2016
Page: [1290 - 1313]
Pages: 24
DOI: 10.2174/1568026615666150915112647
Price: $65

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PDF: 66