Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry

Author(s): Minghao Feng, Bingqing Tang, Steven H. Liang, Xuefeng Jiang

Journal Name: Current Topics in Medicinal Chemistry

Volume 16 , Issue 11 , 2016

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Graphical Abstract:


The impact of the development of sulfur therapeutics is instrumental to the evolution of the pharmaceutical industry. Sulfur-derived functional groups can be found in a broad range of pharmaceuticals and natural products. For centuries, sulfur continues to maintain its status as the dominating heteroatom integrated into a set of 362 sulfur-containing FDA approved drugs (besides oxygen or nitrogen) through the present. Sulfonamides, thioethers, sulfones and Penicillin are the most common scaffolds in sulfur containing drugs, which are well studied both on synthesis and application during the past decades. In this review, these four moieties in pharmaceuticals and recent advances in the synthesis of the corresponding core scaffolds are presented.

Keywords: Sulfur containing drugs, Sulfonamide, Thioether, Sulfones, Sulfur dioxide fixation, Organic synthesis

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Article Details

Year: 2016
Published on: 03 March, 2016
Page: [1200 - 1216]
Pages: 17
DOI: 10.2174/1568026615666150915111741
Price: $65

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