Bispidine as a Privileged Scaffold

Author(s): Isabelle Tomassoli, Daniela Gündisch

Journal Name: Current Topics in Medicinal Chemistry

Volume 16 , Issue 11 , 2016

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Abstract:

Thediazabicyclic molecule bispidine named by the chemist Carl Mannich in 1930, is a naturally occurring scaffold with interesting features. Bispidine can form different conformers, has high basicity, can attack dichloromethane, has metal ion coordination properties and interacts with nicotinic acetylcholine receptors. In this review we will discuss important properties, synthetic pathways and biological activities of bispidine and some derivatives. Bispidine can function as a scaffold for compounds with very diverse biological activities, e.g. interacting with ion channels, G-protein coupled receptors, and enzymes, and is even used for the development of new in vivo radiotracers.

Keywords: Bispidine, cytisine, 3, 7-diazabicyclo[3.3.1]nonane, radiotracer, receptor, scaffold, sparteine.Bispidine, cytisine, 3, 7-diazabicyclo[3.3.1]nonane, radiotracer, receptor, scaffold, sparteine.

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Article Details

VOLUME: 16
ISSUE: 11
Year: 2016
Page: [1314 - 1342]
Pages: 29
DOI: 10.2174/1568026615666150915111434
Price: $65

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