Title:Hydroxamic Acids, Recent Breakthroughs in Stereoselective Synthesis and Biological Evaluations
VOLUME: 13 ISSUE: 5
Author(s):Diana C.G.A. Pinto and Artur M.S. Silva
Affiliation:Department of Chemistry & QOPNA, Aveiro University, 3810-193, Aveiro, Portugal.
Keywords:Biological activities, histone deacetylases, hydroxamic acids, metalloenzyme inhibitors, stereoselectivity, synthetic pathways.
Abstract:Hydroxamic acids attracted much attention due to their ability to coordinate a
range of transition metal ions. Siderophores can be highlighted due to their role as iron carriers
in biological systems. This chelation ability joined to their occurrence in living organisms
lead to their possible use as drugs. One of the most important pharmacological properties is
their ability to inhibit enzymes, activity that can give them properties such as antiinflammatory
and anti-cancer agents. Another important feature resulting from their ability to
form stable chelates is their use as ligands in asymmetric synthesis. In this review, we will
discuss the most recent published results covering the above mentioned aspects.
