The formation of C-C and C-X bonds is a fundamental process in synthesis. In
recent years organocatalysis has become a powerful tool to achieve these steps in a highly
stereoselective manner and the nitro-Michael reaction was frequently used. From the functionalization
of simple aldehydes, ketones or dicarbonyl compounds to the synthesis of privileged
heterocyclic structures often found present in naturally occurring bioactive compounds
and pharmaceuticals, several developments are being continuously documented. This review
is focused on the period Jan 2014-Mar 2015 and it highlights the novel prospects for targetoriented
synthesis, including many novel domino and cascade processes initiated by nitro-Michael reactions.
Keywords: Michael addition, Nitroalkene, Enantioselective, C-C bond formation, Domino, Nitroolefin.
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