Abstract
The formation of C-C and C-X bonds is a fundamental process in synthesis. In recent years organocatalysis has become a powerful tool to achieve these steps in a highly stereoselective manner and the nitro-Michael reaction was frequently used. From the functionalization of simple aldehydes, ketones or dicarbonyl compounds to the synthesis of privileged heterocyclic structures often found present in naturally occurring bioactive compounds and pharmaceuticals, several developments are being continuously documented. This review is focused on the period Jan 2014-Mar 2015 and it highlights the novel prospects for targetoriented synthesis, including many novel domino and cascade processes initiated by nitro-Michael reactions.
Keywords: Michael addition, Nitroalkene, Enantioselective, C-C bond formation, Domino, Nitroolefin.
Graphical Abstract
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
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