Uveitis is a term applied to a broad range of conditions characterized by intraocular inflammation. The
pharmacological treatment of uveitis is controversial, with limited high-level evidence to inform most of the key
treatment decisions that face the patient and clinician on a daily basis. In this review we identified twelve systematic
reviews (including two Cochrane reviews) focused on key therapeutic questions in infectious and noninfectious
uveitis. Our analysis of these reviews demonstrates the paucity of trial evidence available to inform these
important clinical decisions. We consider the reasons for this, and look at the way forward for clinical trials in
uveitis, so that we can move from controversy to clarity in the pharmacotherapy of uveitis.
Keywords: Uveitis, treatment, pharmacotherapy, randomized clinical trial, outcome measures.
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