The study of isatin, as well as its kind of derivatives, has become a hot topic for a long
time. To explore the new compounds and bioactivities, in this work, a series of simple isatin Mannich
and Schiff bases was synthesized through the condensation reaction. The structures of these synthesized compounds were
characterized using NMR and MS. Furthermore, structure of one of these compounds (IMS-4) was studied by using single
crystal X-ray diffraction. Then the anti-tumor and neuro-protection activities of these compounds were evaluated. The results
showed that several compounds show protection activity on the PC12 cells apoptosis induced by H2O2, which are
more effective than that of (±) α-Tocophreol (VE). Besides, some compounds also show anti-tumor activity against A549
and P388 cell lines more potent than that of isatin.