Abstract
Bioreactors are pivotal to the emerging field of tissue engineering. The formation of neotissue from pluripotent cell lineages potentially offers a source of tissue for clinical use without the significant donor site morbidity associated with many contemporary surgical reconstructive procedures. Modern bioreactor design is becoming increasingly complex to provide a both an expandable source of readily available pluripotent cells and to facilitate their controlled differentiation into a clinically applicable ligament or tendon like neotissue. This review presents the need for such a method, challenges in the processes to engineer neotissue and the current designs and results of modern bioreactors in the pursuit of engineered tendon and ligament.
Keywords: Bioreactors, flow perfusion, ligament, rotating wall, spinner flasks, tendon.
Current Stem Cell Research & Therapy
Title:The Role of Bioreactors in Ligament and Tendon Tissue Engineering
Volume: 11 Issue: 1
Author(s): James Mace, Andy Wheelton, Wasim S. Khan and Sanj Anand
Affiliation:
Keywords: Bioreactors, flow perfusion, ligament, rotating wall, spinner flasks, tendon.
Abstract: Bioreactors are pivotal to the emerging field of tissue engineering. The formation of neotissue from pluripotent cell lineages potentially offers a source of tissue for clinical use without the significant donor site morbidity associated with many contemporary surgical reconstructive procedures. Modern bioreactor design is becoming increasingly complex to provide a both an expandable source of readily available pluripotent cells and to facilitate their controlled differentiation into a clinically applicable ligament or tendon like neotissue. This review presents the need for such a method, challenges in the processes to engineer neotissue and the current designs and results of modern bioreactors in the pursuit of engineered tendon and ligament.
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Cite this article as:
Mace James, Wheelton Andy, Khan S. Wasim and Anand Sanj, The Role of Bioreactors in Ligament and Tendon Tissue Engineering, Current Stem Cell Research & Therapy 2016; 11 (1) . https://dx.doi.org/10.2174/1574888X10666150904113827
DOI https://dx.doi.org/10.2174/1574888X10666150904113827 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
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