Developing CXCR4 receptor imaging agents is of great importance for oncological imaging. In this work, N,
N´-[1, 4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane was labeled using high purity [111In]InCl3 in 30-
60 min at 60°C in acetate buffer with acceptable yield and radiochemical purity (>97% ITLC, >95% HPLC, specific
activity: 120-200 GBq/mmol). Radiolabeled complex of AMD-3100 ([111In]-AMD3100) showed good stability at room
temperature and physiologic conditions in human serum for 24 h. Log P for the complex was determined (-1.18) to be
consistent with a water soluble/ionic complex.
The biodistribution of the radiolabeled complex of plerixafor in vital organs of rats was determined up to 48 h
demonstrating kidneys as the major route of excretion. Considering lungs, spleen and liver as the CXCR4 rich target
organs, the best target:non target ratios (for spleen:blood, lung:blood and liver:blood) were obtained 24 h post injection
(5.11, 2.08 and 10.63 respectively).