Ion Selective Electrodes for Potentiometric Determination of Tizanidine in Its Pharmaceutical Dosage Form

Author(s): Gamal Abdel-Hafiz Mostafa, Mohammed Hefnawy, Mohammed Abounassif, Amer Alanazi, Abdulrahman Al-Majed, Atef Homoda

Journal Name: Current Pharmaceutical Analysis

Volume 12 , Issue 3 , 2016

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Graphical Abstract:


The development and general performance of the PVC membrane sensors for tizanidine HCl (Tz) are evaluated. The method included two ion -pair complexes of tizanidine cation and tetraphenyl borate (TPB) or phosphotungstate (PT) as electroactive sensing materials. The characteristic performance of the two sensors was evaluated according to the IUPAC guidelines, which revealed that both sensors show fast, stable and near-Nernstian response over a relatively wide tizanidine concentration range with detection limits of 3 x 10-6 and 2 x 10-6 M for Tz-TPB (sensor 1), and Tz-PT (sensor 2), respectively over a wide pH range of 3.0 - 7.0. The sensors show good selectivity for tizanidine as compared with different ions. The direct determinations of Tz show an average recovery 97.5 and 98.0% and a mean relative standard deviation of 1 . 7 a n d 1 . 5% at 500.0 µg/ml for sensor 1 and sensor 2, respectively. The investigated sensors have been applied for direct determination of Tz in some pharmaceutical preparations. The proposed methods were applied for the determination of Tz in tablets, and the results are compared with those obtained by spectrophotometric method.

Keywords: Tizindine HCl , tetraphenyl borate, phosphotungstic acid, PVC, potentiometry.

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Article Details

Year: 2016
Published on: 26 May, 2016
Page: [177 - 184]
Pages: 8
DOI: 10.2174/1573412911666150901221816
Price: $65

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