Title:Organic and Inorganic Nanoparticles for Prevention and Diagnosis of Gastric Cancer
VOLUME: 21 ISSUE: 29
Author(s):Felipe Oyarzun-Ampuero, Ariel Guerrero, Natalia Hassan-Lopez, Javier O. Morales, Soledad Bollo, Alejandro Corvalan, Andrew F.G. Quest and Marcelo J. Kogan
Affiliation:Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile. Santos Dumont 964, Independencia, Santiago, Chile.
Keywords:Nanocarriers, biomarkers, drug delivery, Helicobacter pylori, gastric cancer, epigenetic.
Abstract:Organic and inorganic nanoparticles show great potential for cancer diagnosis and treatment. Because
gastric cancer (GC) represents the second most deadly type of neoplasia worldwide, continued research efforts by
scientists and clinicians are essential to improve diagnosis and treatment. This paper reviews significant findings in
the area of nanoparticles (organic and inorganic origin) that may aid in prevention and diagnosis of GC. This review
focuses in the first section on H. pylori and the connection to GC, highlighting nanoformulations designed to
control bacterial growth. The second section evaluates the potential of different imaging techniques (especially using
inorganic nanoparticles) in the detection of GC, and the third section summarizes how nanotechnology may be employed in the analytical
detection of GC biomarkers (metallic plasmons, electrochemical biosensors and colorimetric sensors). We foresee that the prevention
and diagnosis of GC will require the development of complex collaborative studies. Additionally, scientists also need to be tightly
connected to industry in order to facilitate upscaling and rapid transfer of promising products to the clinic.
