The Effects of Psychological Stress on Depression

Author(s): Longfei Yang, Yinghao Zhao, Yicun Wang, Lei Liu, Xingyi Zhang, Bingjin Li, Ranji Cui

Journal Name: Current Neuropharmacology

Volume 13 , Issue 4 , 2015

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Graphical Abstract:


Major depressive disorder is a serious mental disorder that profoundly affects an individual's quality of life. Although the aetiologies underlying this disorder remain unclear, an increasing attention has been focused on the influence imposed by psychological stress over depression. Despite limited animal models of psychological stress, significant progress has been made as to be explicated in this review to elucidate the physiopathology underlying depression and to treat depressive symptoms. Therefore, we will review classical models along with new methods that will enrich our knowledge of this disorder.

Keywords: Brain-derived neurotrophic factor, depression, glial cell-derived neurotrophic factor, hippocampus, nucleus accumbens, prefrontal cortex, psychological stress, ventral tegmental area.

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Article Details

Year: 2015
Published on: 30 August, 2015
Page: [494 - 504]
Pages: 11
DOI: 10.2174/1570159X1304150831150507
Price: $65

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