The Morita-Baylis-Hillman reaction is an organocatalyzed chemical transformation
that allows access to small poly-functionalized molecules and has considerable synthetic potential
and promising biological profiles. In this review, we report the efforts made by Brazilian research
groups in recent years on the development of Morita-Baylis-Hillman chemistry. The review covers
these contributions, with a focus on mechanistic studies, improvement of the experimental
conditions, and the use of Morita-Baylis-Hillman adducts as building blocks for the synthesis of
heterocycles, natural products and drugs.
Keywords: Morita-Baylis-Hillman, Heterocycles, Drugs, Acrylates, Mass Spectrometry, Natural Products.
Rights & PermissionsPrintExport