Abstract
The Morita-Baylis-Hillman reaction is an organocatalyzed chemical transformation that allows access to small poly-functionalized molecules and has considerable synthetic potential and promising biological profiles. In this review, we report the efforts made by Brazilian research groups in recent years on the development of Morita-Baylis-Hillman chemistry. The review covers these contributions, with a focus on mechanistic studies, improvement of the experimental conditions, and the use of Morita-Baylis-Hillman adducts as building blocks for the synthesis of heterocycles, natural products and drugs.
Keywords: Morita-Baylis-Hillman, Heterocycles, Drugs, Acrylates, Mass Spectrometry, Natural Products.
Current Organic Synthesis
Title:The Morita-Baylis-Hillman Reaction: Advances and Contributions from Brazilian Chemistry
Volume: 12 Issue: 6
Author(s): Marilia S. Santos, Fernando Coelho, Cláudio G. Lima-Junior and Mário L. A. A. Vasconcellos
Affiliation:
Keywords: Morita-Baylis-Hillman, Heterocycles, Drugs, Acrylates, Mass Spectrometry, Natural Products.
Abstract: The Morita-Baylis-Hillman reaction is an organocatalyzed chemical transformation that allows access to small poly-functionalized molecules and has considerable synthetic potential and promising biological profiles. In this review, we report the efforts made by Brazilian research groups in recent years on the development of Morita-Baylis-Hillman chemistry. The review covers these contributions, with a focus on mechanistic studies, improvement of the experimental conditions, and the use of Morita-Baylis-Hillman adducts as building blocks for the synthesis of heterocycles, natural products and drugs.
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Cite this article as:
Santos S. Marilia, Coelho Fernando, Lima-Junior G. Cláudio and Vasconcellos L. A. A. Mário, The Morita-Baylis-Hillman Reaction: Advances and Contributions from Brazilian Chemistry, Current Organic Synthesis 2015; 12 (6) . https://dx.doi.org/10.2174/157017941206150828114416
DOI https://dx.doi.org/10.2174/157017941206150828114416 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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