Oleanolic acid (3β-hydroxyolean-12-en-28-oic acid) belongs to pentacyclic triterpenoid
compounds which are widely found in natural plants. Oleanolic acid and its derivatives possess
several promising pharmacological activities. The chemical modifications made in the oleanane
backbone mainly at carbons C3, C12 and C28 carboxylic acid, have led to a series of new synthetic
oleanane triterpenoids. The Oleanolic acid derivatives at C-3 position exhibited the most potent
activity. Here, a review of the advances in research on pharmacological activities and synthesis of
Oleanolic acid derivatives at C-3 position are presented.
Keywords: C-3 position, oleanolic acid, oleanolic acid derivatives, pharmacological activities, research, synthesis.
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