The aim of this review paper is to summarize some marine natural sources
(bacteria and fungi) known for their anti-inflammatory effects. We have collected data
from MDPI, current contents, scientific research articles and journal publications. This
review will give brief idea about the chemistry of novel marine compounds, mechanism
of action, metabolites, biological sources of the compounds, synthesis of these marine
natural products, as well as use of them in drug discovery and development. Different
marine bacteria and fungi live in symbiosis with corals or sponges. Many actives have been isolated from these organisms.
The quantity of actives obtained varies in different geographical and environmental conditions. These actives elucidate
different mechanisms of action due to presence of different pharmacophore features in novel chemical templates. Efforts
have been made to synthesize some structural analogs of isolated active anti-inflammatory compounds and SAR studies
conducted. This review gives options for synthesis of new anti-inflammatory compounds thus expanding the chemical
space in this category.
Keywords: Actinobacteria, anti-inflammatory, lactones, marine microbes, sesquiterpenes.
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