Title:Chimeric Antigen Receptor T Cells: Self-Replicating Drugs for Cancer
VOLUME: 18 ISSUE: 3
Author(s):Jan J. Melenhorst, Simon F. Lacey and Felipe Bedoya
Affiliation:University of Pennsylvania, Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, Product Development & Correlative Sciences laboratory, 3400 Civic Center Boulevard, Philadelphia, PA 19104-5156
Keywords:Cell therapy, chimeric antigen receptor (CAR), gene therapy, synthetic biology.
Abstract:The chimeric antigen receptor (CAR) technology started out as a tool to understand lymphocyte
biology but rapidly developed into a T cell therapeutic agent for the treatment of cancers. Here, we
describe the technological advances in the field of CARs and highlight critical components of its success.
Additionally, we describe how various laboratories have worked toward developing new, safer,
and more potent CARs for cancer.
