Title:Anticancer Drug Sensitivity Testing, a Historical Review and Future Perspectives
VOLUME: 10 ISSUE: 1
Author(s):Da-Yong Lu*, Ting-Ren Lu, Jian Ding, Bin Xu, Jin-Yu Che and Hong-Ying Wu
Affiliation:School of Life Sciences, Shanghai University, Shanghai 200444, P.R. China.
Keywords:Anticancer drugs, cancer stem cell, clinical cancer therapy, drug combinations, drug sensitivity
test, individualized cancer therapy, neoplasm metastasis.
Abstract:Background: Clinical cancer treatment and therapy have been gradually improved
by experimental and clinical advancements worldwide, especially after the advent of
different types of individualized cancer therapy (ICT).
Objective: Despite the longest history of anticancer drug sensitivity testing (DST) among
ICT, its therapeutic applications for clinical cancer trials need to be updated.
Methods: DST techniques are widely diversified and improved a great deal, but they have
not been matured to cure all cancer patients in clinics.
Results: The retrospection and panorama of historic and evolutionary developments of DST
including clinical relevance, advantageous, technical cautions, limitations of varied models and methodologies
at present stage are addressed.
Conclusion: Future directions and novel ideas must be established.
