One-Step Synthesis of 1H-1,2,3-Triazol-1-Ylmethyl-2,3-Dihydronaphtho[1,2-b]furan- 4,5-Diones

Author(s): Ingrid C. Chipoline, Vitor F. Ferreira, Fernando de C. da Silva

Journal Name: Current Organic Synthesis

Volume 12 , Issue 5 , 2015


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Abstract:

We report herein a straightforward and efficient route to prepare 1H-1,2,3-triazoles-linked to 2,3- dihydronaphtho[1,2-b]furan-4,5-dione in C-2 in a one-step reaction from readily available starting materials. We performed a one-step procedure from iodocyclization of 3-allyl-lawsone followed by a nucleophilic substitution reaction of the iodized product, and finally the Huisgen 1,3-dipolar cycloaddition reaction catalyzed by Cu(I) provide 1H-1,2,3-triazol-1-ylmethyl-2,3-dihydronaphtho[1,2-b]furan-4,5-diones.

Keywords: Quinones, nor-Lapachones, 1, 2, 3-triazoles, one-pot reactions.

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Article Details

VOLUME: 12
ISSUE: 5
Year: 2015
Page: [565 - 569]
Pages: 5
DOI: 10.2174/157017941205150821125159
Price: $65

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