Abstract
Cryptomoscatones D1 and D2, dihydropyranones isolated from C. mandiocanna, had their stereochemistry solved after total syntheses and comparison of spectroscopic data of natural and synthetic samples. Natural dihydropyranones coibacins A and B, metabolites isolated from marine cyanobacterium cf. Oscillatoria sp, which display antileishmanial activity and anti-inflammatory properties, were synthesized and had their absolute configuration determined. Our efforts towards the synthesis of cryptomoscatone E3, natural dihydropyranone with unknown absolute configuration, are also discussed.
Keywords: Polyketides, Total Synthesis, Structural Elucidation, Coibacin, Cryptomoscatone.
Current Organic Synthesis
Title:Total Synthesis of Natural Dihydropyranones: A Contribution to the Structural Elucidation of Natural Products. Coibacins A and B, Cryptomoscatones D1, D2 and E3
Volume: 12 Issue: 5
Author(s): Ronaldo Aloise Pilli, Luiz Fernando Toneto Novaes, Vânia Maria Teixeira Carneiro, Roberta Lopes Drekener and Carolina Martins Avila
Affiliation:
Keywords: Polyketides, Total Synthesis, Structural Elucidation, Coibacin, Cryptomoscatone.
Abstract: Cryptomoscatones D1 and D2, dihydropyranones isolated from C. mandiocanna, had their stereochemistry solved after total syntheses and comparison of spectroscopic data of natural and synthetic samples. Natural dihydropyranones coibacins A and B, metabolites isolated from marine cyanobacterium cf. Oscillatoria sp, which display antileishmanial activity and anti-inflammatory properties, were synthesized and had their absolute configuration determined. Our efforts towards the synthesis of cryptomoscatone E3, natural dihydropyranone with unknown absolute configuration, are also discussed.
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Pilli Aloise Ronaldo, Toneto Novaes Fernando Luiz, Teixeira Carneiro Maria Vânia, Drekener Lopes Roberta and Avila Martins Carolina, Total Synthesis of Natural Dihydropyranones: A Contribution to the Structural Elucidation of Natural Products. Coibacins A and B, Cryptomoscatones D1, D2 and E3, Current Organic Synthesis 2015; 12 (5) . https://dx.doi.org/10.2174/157017941205150821121851
DOI https://dx.doi.org/10.2174/157017941205150821121851 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
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