Abstract
Epilepsy is one of the most common neurological disorders in humans, and the role of cerebellum in its physiopathology remains the subject of study. Bergmann glia in the cerebellar cortex regulates the homeostasis of Purkinje cells, the axons of which target the dentate and interpositus nuclei, which form the main cerebellar output to other structures in the central nervous system involved in Epilepsy. Sox-1 is a transcription factor expressed in Bergmann glia and its binding to β-Catenin further inhibits the Wnt pathway. β-Catenin is widely expressed in cerebellum. It has been reported that β-Catenin signaling is increased as the hippocampus receives repeated electrical stimuli and this is related with apoptosis of neurons. In the cerebellum, the recurrence of seizures results in Purkinje cells death, although the mechanisms remain unclear.
Keywords: Epilepsy, Cerebellum, Bergmann glia, Sox-1, β-catenin, Apoptosis.
CNS & Neurological Disorders - Drug Targets
Title:Commentary: Participation of Sox-1 Expression and Signaling of β-Catenin in the Pathophysiology of Generalized Seizures in Cerebellum of Rat
Volume: 15 Issue: 1
Author(s): Artemio Rosiles, Carmen Rubio, Cristina Trejo, Jessica Gutierrez, Leonardo Hernández and Carlos Paz
Affiliation:
Keywords: Epilepsy, Cerebellum, Bergmann glia, Sox-1, β-catenin, Apoptosis.
Abstract: Epilepsy is one of the most common neurological disorders in humans, and the role of cerebellum in its physiopathology remains the subject of study. Bergmann glia in the cerebellar cortex regulates the homeostasis of Purkinje cells, the axons of which target the dentate and interpositus nuclei, which form the main cerebellar output to other structures in the central nervous system involved in Epilepsy. Sox-1 is a transcription factor expressed in Bergmann glia and its binding to β-Catenin further inhibits the Wnt pathway. β-Catenin is widely expressed in cerebellum. It has been reported that β-Catenin signaling is increased as the hippocampus receives repeated electrical stimuli and this is related with apoptosis of neurons. In the cerebellum, the recurrence of seizures results in Purkinje cells death, although the mechanisms remain unclear.
Export Options
About this article
Cite this article as:
Rosiles Artemio, Rubio Carmen, Trejo Cristina, Gutierrez Jessica, Hernández Leonardo and Paz Carlos, Commentary: Participation of Sox-1 Expression and Signaling of β-Catenin in the Pathophysiology of Generalized Seizures in Cerebellum of Rat, CNS & Neurological Disorders - Drug Targets 2016; 15 (1) . https://dx.doi.org/10.2174/1871527314666150821105001
DOI https://dx.doi.org/10.2174/1871527314666150821105001 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
Call for Papers in Thematic Issues
Diagnosis and treatment of central nervous system infectious diseases
Infectious diseases of the central nervous system (CNS) can be divided into bacterial, tuberculous, viral, fungal, parasitic infections, etc. Early etiological treatment is often the most crucial means to reduce the mortality rate of patients with central nervous system infections, reduce complications and sequelae, and improve prognosis. The initial clinical ...read more
Techniques of Drug Repurposing: Delivering a new life to Herbs & Drugs
Of late, with the adaptation of innovative approaches and integration of advancements made towards medical sciences as well as the availability of a wide range of tools; several therapeutic challenges are being translated into viable clinical solutions, with a high degree of efficacy, safety, and selectivity. With a better understanding ...read more
Trends and perspectives in the rational management of CNS disorders
Central nervous system (CNS) diseases enforce a significant global health burden, driving ongoing efforts to improve our understanding and effectiveness of therapy. This issue investigates current advances in the discipline, focusing on the understanding as well as therapeutic handling of various CNS diseases. The issue covers a variety of diseases, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Role of Cannabinoids and Endocannabinoids in Cerebral Ischemia
Current Pharmaceutical Design Hormone Replacement Therapy and Stroke
Current Vascular Pharmacology Anticonvulsants – Antidepressants Pharmacokinetic Drug Interactions: The Role of the CYP450 System in Psychopharmacology
Current Drug Metabolism Antiepileptic Treatment Strategy in Vascular Malformations
Current Pharmaceutical Design Gliomas: Current Issues in Diagnosis and Treatment
Current Medical Imaging Bispidine as a Privileged Scaffold
Current Topics in Medicinal Chemistry Recent Advances in the Discovery of α1-Adrenoceptor Agonists
Current Topics in Medicinal Chemistry Antiphospholipid Syndrome as a Neurological Disease
Current Rheumatology Reviews The Role of Therapeutic Drugs on Acquired Mitochondrial Toxicity
Current Drug Metabolism Magnolia officinalis Reduces Inflammation and Damage Induced by Recurrent Status Epilepticus in Immature Rats
Current Pharmaceutical Design Molecular Mechanisms Underlying Specificity of Excitotoxic Signaling in Neurons
Current Molecular Medicine Preface: Vitamin D and QT Interval in Epilepsy: More than an Association?
Current Clinical Pharmacology A Timely Review of State-of-the-Art Chronopharmaceuticals Synchronized with Biological Rhythms
Current Drug Delivery Venom Peptide Modulators of the Immune System
Inflammation & Allergy - Drug Targets (Discontinued) Voltage-Gated Sodium Channel Blockers; Target Validation and Therapeutic Potential
Current Topics in Medicinal Chemistry Pharmacotherapy of Borderline Personality Disorder: A Systematic Review
Current Medicinal Chemistry Catatonia: A Narrative Review
Central Nervous System Agents in Medicinal Chemistry Bipolar Spectrum Disorder: Origins and State of the Art
Current Psychiatry Reviews The Blood-Brain Barrier in Multiple Sclerosis: microRNAs as Key Regulators
CNS & Neurological Disorders - Drug Targets Advances in Pediatric Epilepsy Surgery
Current Pediatric Reviews