Osteogenic differentiation of skeletal stem cells is an integral part of bone development and
homeostasis, and the perturbation of this process is one of the causes to skeletal disease. Understanding
of how epigenetic events regulate skeletal stem cell differentiation is therefore of great importance.
While the basic epigenetic modifications leading to bone formation are somewhat under explored, a
significant amount of research has defined the regulatory roles of histone modifications in osteogenic differentiation. The
orchestration of histone modifications is a requirement to establish the epigenetic status which regulates gene transcription
during osteogenic differentiation of skeletal stem cells. Here we focus on the roles of histone modification during osteogenic
differentiation and review studies that have advanced our knowledge in the field. Before this summary, a brief
description is given regarding the up-to-date understanding of the definition of skeletal stem cells and the main mechanisms
responsible for histone modifications.
Keywords: Epigenetics, histone modification, osteogenic differentiation, skeletal stems cells.
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