Abstract
Endothelial dysfunction (ED) is the initial step in the development of atherosclerosis, leading to cardiovascular disease (CVD). It has been suggested that periodontal disease (PD) could be associated to pathogenesis of atherosclerosis, since it is able to trigger a host response with systemic inflammation. Although a number of epidemiological studies have shown that periodontitis could be associated with ED, it is still unclear whether periodontal treatment could improve ED and therefore cardiovascular outcomes. In this narrative review we analysed the literature in the databases of Medline under ‘‘endothelial function OR dysfunction OR vasodilatation’’, AND ‘‘periodontal disease” OR periodontal treatment” AND “cardiovascular disease” OR atherosclerosis AND “endothelial biomarker”. Research articles, systematic reviews and clinical trials were screened. ED could be related to periodontitis as well as to CVD. Periodontal treatment reduces the risk of teeth loss and may improve ED and the risk of CVD. Since controversial results exist, there is an urgent need for well-designed clinical trials to find and validate novel biomarkers of endothelial function, such as circulating endothelial progenitors, which may be crucial for further investigation of the association of PD with endothelial function and CVD.
Keywords: Endothelial dysfunction, cardiovascular disease, periodontal disease, antimicrobial therapy, endothelial biomarkers, endothelial progenitors.
Current Vascular Pharmacology
Title:Treatment of Periodontitis for the Prevention of Endothelial Dysfunction: A Narrative Review
Volume: 13 Issue: 6
Author(s): Astrid Parenti, Sara Paccosi, Francesco Cairo and Efisio Defraia
Affiliation:
Keywords: Endothelial dysfunction, cardiovascular disease, periodontal disease, antimicrobial therapy, endothelial biomarkers, endothelial progenitors.
Abstract: Endothelial dysfunction (ED) is the initial step in the development of atherosclerosis, leading to cardiovascular disease (CVD). It has been suggested that periodontal disease (PD) could be associated to pathogenesis of atherosclerosis, since it is able to trigger a host response with systemic inflammation. Although a number of epidemiological studies have shown that periodontitis could be associated with ED, it is still unclear whether periodontal treatment could improve ED and therefore cardiovascular outcomes. In this narrative review we analysed the literature in the databases of Medline under ‘‘endothelial function OR dysfunction OR vasodilatation’’, AND ‘‘periodontal disease” OR periodontal treatment” AND “cardiovascular disease” OR atherosclerosis AND “endothelial biomarker”. Research articles, systematic reviews and clinical trials were screened. ED could be related to periodontitis as well as to CVD. Periodontal treatment reduces the risk of teeth loss and may improve ED and the risk of CVD. Since controversial results exist, there is an urgent need for well-designed clinical trials to find and validate novel biomarkers of endothelial function, such as circulating endothelial progenitors, which may be crucial for further investigation of the association of PD with endothelial function and CVD.
Export Options
About this article
Cite this article as:
Parenti Astrid, Paccosi Sara, Cairo Francesco and Defraia Efisio, Treatment of Periodontitis for the Prevention of Endothelial Dysfunction: A Narrative Review, Current Vascular Pharmacology 2015; 13 (6) . https://dx.doi.org/10.2174/1570161113666150818110653
DOI https://dx.doi.org/10.2174/1570161113666150818110653 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
Call for Papers in Thematic Issues
Ischemic Cardiovascular Diseases: Mechanisms, Diagnosis and Therapy
Ischemic cardiovascular disease includes myocardial infarction, coronary atherosclerotic heart disease, angina pectoris, etc., constitute the leading cause of patient mortality by preventing tissues from getting sufficient oxygen and nutrients. Ischemic heart disease, as a clinical condition, is characterized by myocardial ischemia, causing an imbalance between myocardial blood supply and demand, ...read more
TREATMENT OF CARDIOVASCULAR DISEASE IN CHRONIC AND END STAGE KIDNEY DISEASE
Cardiovascular disease still remains the leading cause of death in Chronic and End Stage Kidney Disease, accounting for more than half of all deaths in dialysis patients. During the past decade, research has been focused on novel therapeutic agents that might delay or even reverse cardiovascular disease and vascular calcification, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Treating Dyslipidemias: Is Inflammation the Missing Link?
Medicinal Chemistry Acute and Long-Term Effects of Cannabis Use: A Review
Current Pharmaceutical Design Central Regulatory Role of Cytokines in Periodontitis and Targeting Options
Current Medicinal Chemistry Formulation Development, Physicochemical Characterization and In Vitro-In Vivo Drug Release of Vaginal Films
Current HIV Research Strategies for Antimicrobial Drug Delivery to Biofilm
Current Pharmaceutical Design Melatonin as a Pleiotropic Molecule with Therapeutic Potential for Type 2 Diabetes and Cancer
Current Medicinal Chemistry Cytotoxic, Antiproliferative and Apoptotic Effects of New Benzimidazole Derivatives on A549 Lung Carcinoma and C6 Glioma Cell Lines
Anti-Cancer Agents in Medicinal Chemistry The Antidiabetic Therapeutic Potential of Dietary Polyphenols
Current Pharmaceutical Biotechnology Edible Transgenic Plant Vaccines for Different Diseases
Current Pharmaceutical Biotechnology The Importance of Drug Delivery to Optimize the Effects of Bone Morphogenetic Proteins During Periodontal Regeneration
Current Pharmaceutical Biotechnology On the Involvement of H2S in Nitroso Signaling and Other Mechanisms of H2S Action
Current Pharmaceutical Biotechnology Medicinal Properties of Mangiferin, Structural Features, Derivative Synthesis, Pharmacokinetics and Biological Activities
Mini-Reviews in Medicinal Chemistry Bioreactors Design, Types, Influencing Factors and Potential Application in Dentistry. A Literature Review
Current Stem Cell Research & Therapy Cytotoxic, Apoptotic and DNA Synthesis Inhibitory Effects of Some Thiazole Derivatives
Letters in Drug Design & Discovery The Rationale of Targeting Neutrophils with Dapsone during Glioblastoma Treatment
Anti-Cancer Agents in Medicinal Chemistry Targeting of Nuclear Factor-κB and Proteasome by Dithiocarbamate Complexes with Metals
Current Pharmaceutical Design Osteoimmunology and Beyond
Current Medicinal Chemistry Mucoadhesive Buccal Systems as a Novel Strategy for Anti-Inflammatory Drugs Administration
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Anti-inflammatory Action of Green Tea
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Interleukins Involved in Inflammatory Bowel Disease as New Therapeutic Targets
Current Immunology Reviews (Discontinued)