Tuberculosis (TB) is an infectious disease caused by bacterium of the Mycobacterium
genus, mainly by Mycobacterium tuberculosis (MTB). The World Health Organization
aims to substantially reduce the number of cases in the coming years; however, the increased
number of multidrug-resistant (MDR) and extremely drug-resistant (XDR) forms of
the bacterium and the lack of treatment for latent tuberculosis are challenges to be overcome.
In this review, we have identified the most potent compounds described in the literature
during recent years with MIC values < 7 µM, low toxicity and a high selective index. In
addition, emerging targets in MTB are presented to provide new perspectives for the discovery
of new antitubercular drugs. This review aims to summarize the current advances in and promote insights
into antitubercular drug discovery.
Keywords: Antitubercular drugs, drug discovery, Mycobacterium tuberculosis, resistant tuberculosis, tuberculosis,
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