miRNAs in Bone Development

Author(s): Garyfallia Papaioannou

Journal Name: Current Genomics

Volume 16 , Issue 6 , 2015

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Abstract:

Skeletal development is a multistage process during which mesenchymal progenitor cells undergo proliferation and differentiation and subsequently give rise to bone and cartilage forming cells. Each step is regulated by various transcription factors and signaling molecules. microRNAs are small non-coding RNAs that post-transcriptionally regulate gene expression. Several in vivo and in vitro studies have shown that miRNAs play significant roles in skeletal development. Identifying their functions may give insights into the treatment of developmental disorders of the skeleton. This review summarizes miRNAs that have been shown to participate in various stages of skeletal development by targeting crucial factors.

Keywords: Bone, Cartilage, Chondrocytes, Mesenchymal stem cells, mi-RNAs, Osteoblasts, Skeletal development.

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Article Details

VOLUME: 16
ISSUE: 6
Year: 2015
Page: [427 - 434]
Pages: 8
DOI: 10.2174/1389202916666150817202425
Price: $65

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