Skeletal development is a multistage process during which mesenchymal progenitor cells
undergo proliferation and differentiation and subsequently give rise to bone and cartilage forming
cells. Each step is regulated by various transcription factors and signaling molecules. microRNAs are
small non-coding RNAs that post-transcriptionally regulate gene expression. Several in vivo and in vitro
studies have shown that miRNAs play significant roles in skeletal development. Identifying their
functions may give insights into the treatment of developmental disorders of the skeleton. This review
summarizes miRNAs that have been shown to participate in various stages of skeletal development by
targeting crucial factors.
Keywords: Bone, Cartilage, Chondrocytes, Mesenchymal stem cells, mi-RNAs, Osteoblasts, Skeletal development.
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