The Developmental Origins of Osteoporosis

Author(s): Claire L Wood, Charlotte Stenson, Nicholas Embleton

Journal Name: Current Genomics

Volume 16 , Issue 6 , 2015

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Graphical Abstract:


Osteoporosis is one of the most prevalent skeletal disorders and has enormous public health consequences due to the morbidity and mortality of the resulting fractures. This article discusses the developmental origins of osteoporosis and outlines some of the modifiable and non-modifiable risk factors in both intrauterine and postnatal life that contribute to the later onset of osteoporosis. Evidence for the effects of birth size and early growth in both preterm and term born infants are discussed and the role of epigenetics within the programming hypothesis is highlighted. This review provides compelling evidence for the developmental origins of osteoporosis and highlights the importance of osteoporosis prevention at all stages of the life course.

Keywords: Bone mineral density, Life course, Programming, Osteoporosis.

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Article Details

Year: 2015
Published on: 17 August, 2015
Page: [411 - 418]
Pages: 8
DOI: 10.2174/1389202916666150817202217
Price: $65

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