For more than 30 years, lipid droplets (LDs) were considered as an inert bag of lipid for
storage of energy-rich fat molecules. Following a paradigm shift almost a decade ago, LDs are presently
considered an active subcellular organelle especially designed for assembling, storing and subsequently
supplying lipids for generating energy and membrane synthesis (and in the case of hepatocytes
for VLDL secretion). LDs also play a central role in many other cellular functions such as viral assembly
and protein degradation. Here, we have explored the structural and functional changes that occur in
hepatic and adipose tissue LDs following chronic ethanol consumption in relation to their role in the
pathogenesis of alcoholic liver injury.
Keywords: Liver, alcohol, steatosis, lipid, triglycerides, adipose, lipid droplet, perilipin, phosphatidylcholine, phosphatidylethanolamine,
lipases, ATGL, HSL, TGH, lipolysis, lipophagy, VLDL, rab, dynamin, Src, HCV, MiRs, betaine.
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