Peptides are being successfully used in various fields including therapy and drug delivery.
With advancement in nanotechnology and targeted delivery carrier systems, suitable modification of
peptides has enabled achievement of many desirable goals over-riding some of the major disadvantages
associated with the delivery of peptides in vivo. Conjugation or physical encapsulation of peptides
to various nanocarriers, such as liposomes, micelles and solid-lipid nanoparticles, has improved
their in vivo performance multi-fold. The amenability of peptides to modification in chemistry and
functionalization with suitable nanocarriers are very relevant aspects in their use and have led to the
use of ‘smart’ nanoparticles with suitable linker chemistries that favor peptide targeting or release at the desired sites,
minimizing off-target effects. This review focuses on how nanotechnology has been used to improve the number of peptide
applications. The paper also focuses on the chemistry behind peptide conjugation to nanocarriers, the commonly employed
linker chemistries and the several improvements that have already been achieved in the areas of peptide use with
the help of nanotechnology.
Keywords: Applications, Carriers, Chemistry, Linkers, Nanotechnology, Peptides, Targeted delivery.
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