Title:Metalloprotein Inhibitors for the Treatment of Human Diseases
VOLUME: 16 ISSUE: 4
Author(s):Yang Yang, Xue-Qin Hu, Qing-Shan Li, Xing-Xing Zhang, Ban-Feng Ruan, Jun Xu and Chenzhong Liao
Affiliation:School of Medical Engineering, Hefei University of Technology, Hefei 230009, P.R. China.
Keywords:Chelating, Drug design, Drug development, Magnesium, Metalloprotein, Zinc.
Abstract:Metalloproteins have attracted momentous attentions for the treatment of many human diseases,
including cancer, HIV, hypertension, etc. This article reviews the progresses that have been
made in the field of drug development of metalloprotein inhibitors, putting emphasis on the targets of
carbonic anhydrase, histone deacetylase, angiotensin converting enzyme, and HIV-1 integrase. Many
other important metalloproteins are also briefly discussed. The binding and coordination modes of different
marketed metalloprotein inhibitors are stated, providing insights to design novel metal binding
groups and further novel inhibitors for metalloproteins.
