A series of symmetrical Schiff base derivatives (L1-L7) were designed by a one-pot condensation reaction of
various aldehyde/ketone compounds with hydrazine under mild conditions (room temperature, 3 days), using ether as solvent
and acetic acid as catalyst. The target products were characterized and analysed by 1H and 13C NMR, FT-IR and liquid
chromatography mass spectrometry (LC/MS). Our research focuses on the identification of synthetically chemotherapeutic
substances able to inhibit, delay, or reverse the process of carcinogenesis in several stages. The target compounds
presenting two regions for SAR evaluation were screened for their activity toward MDA-MB-241 breast cancer cell proliferation
for the first time. Compound (1E, 2E)-1,2-bis(1-(3-nitrophenyl)ethylidene) hydrazine (L6) showed significant
inhibitory activity (IC50 = 7.08 µg/mL).
Keywords: Schiff bases, heterocycles, nitro, antitumor activity, breast cancer, cell proliferation.
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