Abstract
The study of quinoxalines has increased immeasurably during the last two decades, due firstly to their relatively simple chemical synthesis, which has generated a vast variety of compounds with diverse structural modifications, and secondly, to the wide therapeutic potential and biological activities exhibited by this family of compounds. Quinoxalines constitute a rising biomedical class of low-molecular weight heterocyclic compounds with potential functions as antitumour, anti-inflammatory, antibacterial, antiviral, antifungal, antiparasitic and antidiabetic agents, as well as being of interest for the potential treatment of glaucoma, insomnia, cardiovascular and neurological diseases, among others. However, a deeper knowledge of the molecular targets of quinoxalines that fulfil a key role in certain pathologies is required for the development of new and more specific drugs through a rational design strategy to avoid undesirable side effects. In the present review, we summarize the most important molecular targets of the quinoxaline derivatives discovered to date, thus providing a first reference index for researchers to identify the potential targets of their quinoxalines derived collections, which could facilitate the development of new quinoxaline- based therapies.
Keywords: Biomedical activity, Intracellular signaling, Molecular targets, Receptors, Quinoxaline derivatives, Therapeutic applications.
Current Medicinal Chemistry
Title:Quinoxalines Potential to Target Pathologies
Volume: 22 Issue: 26
Author(s): Maria Tristan-Manzano, Antonio Guirado, Maria Martinez-Esparza, Jesus Galvez, Pilar Garcia-Penarrubia and Antonio J. Ruiz-Alcaraz
Affiliation:
Keywords: Biomedical activity, Intracellular signaling, Molecular targets, Receptors, Quinoxaline derivatives, Therapeutic applications.
Abstract: The study of quinoxalines has increased immeasurably during the last two decades, due firstly to their relatively simple chemical synthesis, which has generated a vast variety of compounds with diverse structural modifications, and secondly, to the wide therapeutic potential and biological activities exhibited by this family of compounds. Quinoxalines constitute a rising biomedical class of low-molecular weight heterocyclic compounds with potential functions as antitumour, anti-inflammatory, antibacterial, antiviral, antifungal, antiparasitic and antidiabetic agents, as well as being of interest for the potential treatment of glaucoma, insomnia, cardiovascular and neurological diseases, among others. However, a deeper knowledge of the molecular targets of quinoxalines that fulfil a key role in certain pathologies is required for the development of new and more specific drugs through a rational design strategy to avoid undesirable side effects. In the present review, we summarize the most important molecular targets of the quinoxaline derivatives discovered to date, thus providing a first reference index for researchers to identify the potential targets of their quinoxalines derived collections, which could facilitate the development of new quinoxaline- based therapies.
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Cite this article as:
Tristan-Manzano Maria, Guirado Antonio, Martinez-Esparza Maria, Galvez Jesus, Garcia-Penarrubia Pilar and Ruiz-Alcaraz J. Antonio, Quinoxalines Potential to Target Pathologies, Current Medicinal Chemistry 2015; 22 (26) . https://dx.doi.org/10.2174/0929867322666150812144104
DOI https://dx.doi.org/10.2174/0929867322666150812144104 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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