Many herbal medicines and drugs are available in the clinic as potent hepatoprotective agents for the
treatment of commonly occurring liver diseases. Recently, herbal medicines such as silymarin and curcumin have
gained more attention and popularity for the treatment of various liver diseases because of their safety and efficacy
profiles. Some of them are related to transporters for drug disposition processes, therapeutic efficacy and/or adverse
drug reactions. Currently, herbal medicines and diet supplements made from natural products are widely used
in patients who are being treated with conventional prescription medicines, which are related to an increasing risk
of herbal-drug interactions (HDIs) and/or drug–drug interactions (DDIs). The purpose of present review is to summarize the contemporary
knowledge of transporter-mediated HDIs or DDIs for herbal medicines/drugs focusing on hepatoprotective compounds. Several
herbal medicines/drugs are discussed in detail in this review.
Keywords: ABC transporters, drug-drug interaction, herbal-drug interaction, herbal medicine, liver protective drug, SLC transporters.
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