Title:Research Advances in the Treatment of Melanoma by Treat Melanoma
VOLUME: 16 ISSUE: 2
Author(s):Can Liu, Si-Qi He, Xiao-Qing Chen, Hui-Qing Xie, Yong Chen, Rui Liu, Ke Cao and Jian-Da Zhou
Affiliation:Department of Plastic Surgery, the Third Xiangya Hospital, Central South University, Changsha, China.
Keywords:Immunogenicity, Melanoma, Multipeptide vaccines, Melanoma-Associated protein 100, Survivin, Immune adjuvants.
Abstract:Melanoma is a highly malignant tumor. Prognoses of melanoma patients are often unsatisfactory
due to poor operational and chemoradiational efficacy. Recently, researches for melanoma
treatment have found multipeptide vaccines a favorite and possible breakthrough as they are stable in
chemical property and easy to be synthesized, have no carcinogenecity and dispense with virus vector.
Studies have shown that the immunogenicity of multipeptide vaccines could be enhanced by use of immunoadjuvants,
joining dendritic cells (DCs), full-length or epitope-superposited antigen peptides, costimulatory molecules and cellpenetrating
peptides fusion, thereby improving anti-tumor effect. Certain achievements have been obtained in clinical
treatment of melanoma by multipeptide vaccines, but problems including poor immunogenicity and human leukocyte antigen
(HLA) phenotype restriction may require further study.
