Targeting Interferon Regulatory Factor for Cardiometabolic Diseases: Opportunities and Challenges

Author(s): Yaxing Zhang, Xiao-Jing Zhang, Hongliang Li*

Journal Name: Current Drug Targets

Volume 18 , Issue 15 , 2017

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Graphical Abstract:


Background: The pathological activation of innate immune system may contribute to the development of cardiometabolic diseases. The interferon regulatory factor (IRF) family members, which are the major transcription factors in innate immune signaling, are implicated in cardiometabolic diseases.

Objective: The aim of this review is to summary the current knowledge of the biological functions of IRFs in innate immune responses and immune cell development, and highlight our contemporary understanding of the functions and molecular mechanisms of IRFs in metabolic diseases, cardiovascular remodeling, and stroke.

Results: IRFs are the essential regulators of cardiometabolic diseases via immune-dependent and - independent manners.

Conclusion: IRFs signaling is the promising target to manage the initiation and progression of cardiometabolic disorders.

Keywords: Interferon regulatory factor signaling, metabolic diseases, cardiac remodeling, vascular injury, stroke, vascular remodeling.

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Article Details

Year: 2017
Page: [1754 - 1778]
Pages: 25
DOI: 10.2174/1389450116666150804110412
Price: $65

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PDF: 30