Bischler-Napieralski (B-N) reaction is undoubtedly one of the most powerful methodologies in organic
synthesis for the construction of isoquinoline moieties as important heterocyclic compounds. It has also captured
great attention in the total synthesis of naturally occurring compounds such as alkaloids, which mostly and particularly
bear isoquinolines as scaffold in their structures. The present review is focused on and highlighted the applications of
B-N reaction, a rather old reaction, as a decisive and important stage in the total synthesis of some naturally occurring
compounds including alkaloids showing significant biological activities.
Keywords: Bischler-Napieralski reaction, isoquinoline, natural product, alkaloids, total synthesis.
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