The Effects of Vitamin C on Adriamycin-Induced Hypercholesterolemia in Rat

Author(s): Reza Mohebbati, Abolfazl K. Rad, Mohammad N. Shafei, Mohammad Soukhtanloo, Sara Hosseinian, Farimah Beheshti, Mohammad R. Khazdair

Journal Name: Current Nutrition & Food Science

Volume 11 , Issue 4 , 2015

Become EABM
Become Reviewer

Graphical Abstract:


This study investigated the influence of Vitamin C (Vit C) on Adriamycin-induced hypercholesterolemia and body weight in rats.

Sixty-four male Albino Wistar rats were divided into eight groups : Control (CO), Adriamycin (ADR), three groups received different doses of Vit C and three groups received Adriamycin plus different doses of Vitamin C (ADR +Vit C).

ADR treated rats showed an insignificant increase in serum cholesterol levels compared with the control group (animals). ADR+Vit C groups showed a significant increase of serum cholesterol level compared to the control group. Meanwhile, body weight in ADR treated rats decreased compared with the control group but this reduction was not significant). Body weight in ADR+Vit C groups demonstrated a significant decrease compared to the control animals.

Conclusion: Findings of the current study imply that treatment with different doses of Vitamin C have possibly deleterious effects on Adriamycin-induced hypercholesterolemia as a dose dependent manner and body weight in rat.

Keywords: Adriamycin, vitamin c, hypercholesterolemia.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2015
Page: [309 - 314]
Pages: 6
DOI: 10.2174/1573401311666150729230335
Price: $65

Article Metrics

PDF: 20