The Role of Topiramate in the Management of Cocaine Addiction: a Possible Therapeutic Option

Author(s): Antonio Siniscalchi, Antonello Bonci, Nicola Biagio Mercuri, Domenico Pirritano, Aida Squillace, Giovambattista De Sarro, Luca Gallelli

Journal Name: Current Neuropharmacology

Volume 13 , Issue 6 , 2015

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Graphical Abstract:


Topiramate (TPM) is an antiepileptic drug able to play a role in both neurological and psychiatric disorders. TPM facilitates gamma-aminobutyric acid (GABA) transmission and inhibits glutamatergic transmission (i.e. AMPA/kainate receptors).

Several studies reported that the modulation of GABAergic and glutamatergic synaptic transmission may reduce cocaine reinforcement. Therefore, TPM could be used in the management of cocaine dependence.

Keywords: Cocaine dependence, gamma-aminobutyric acid neurotransmission, glutamatergic neurotransmission, topiramate.

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Article Details

Year: 2015
Page: [815 - 818]
Pages: 4
DOI: 10.2174/1570159X13666150729222643
Price: $65

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PDF: 12