Hydrazones as a Privileged Structural Linker in Antitubercular Agents: A Review

Author(s): Bijo Mathew, Jerad Suresh, Mohamed J. Ahsan, Githa E. Mathew, Dhasthakeer Usman, Puthucode N.S. Subramanyan, Kallivalappil F. Safna, Srinubabu Maddela

Journal Name: Infectious Disorders - Drug Targets
(Formerly Current Drug Targets - Infectious Disorders)

Volume 15 , Issue 2 , 2015

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Graphical Abstract:


Hydrazones are a versatile linker of connecting various classes of organic compounds with a unique structural feature of hydrogen bonding donor and the hydrogen bonding acceptor region. An extensive number of research has been carried out on hydrazone derivatives as a potent class of antitubercular agents. The present review focuses on the chemistry, antitubercular activity and structure activity relationship (SAR) of diverse classes of phenyl and heterocyclic based hydrazones.

Keywords: Alamar blue assay, nucleophilic addition, tuberculosis.

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Article Details

Year: 2015
Page: [76 - 88]
Pages: 13
DOI: 10.2174/1871526515666150724104411
Price: $65

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PDF: 43